Generic phenytoin vs dilantin
Generic Phenytoin Vs Dilantin
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Max oral dose of phenytoin, a diuretic, was estimated in the two studies to be approximately 600 mg/day. There is insufficient information to determine whether the effect on cognition can be reduced when phenytoin is combined with another drug (e.g., an anticholinergic). The effects of phenytoin on motor activity have not been studied to the extent necessary determine whether combined use of phenytoin and an anticholinergic may interfere with motor activities. Phenytoin may increase blood pressure and london drug stores in canada cause serious vascular effects in individuals with heart or blood vessel diseases. Some individuals taking phenytoin may experience increased fatigue and sleepiness. The potential for concomitant use with other depressants should be carefully considered. The use of concomitant benzodiazepines may increase phenytoin's sedative effects. Phenytoin has been shown to produce a significant increase in the incidence of psychiatric disorders such as obsessive-compulsive disorder. These disorders can be treated effectively with phenytoin sodium generic appropriate psychotherapy. Phenytoin may cause an increase in blood pressure. Therefore, phenytoin pressure should be monitored closely. Phenytoin is extensively metabolized by cytochrome P450, mainly monoamine oxidase (MAO). Concomitant administration of phenytoin and alcohol may increase the development of CNS depression and, hence, the risk of cardiovascular side effects. Taking other medications concurrently increases the risk of adverse reactions. generic for phenytoin Such potential reactions may include increased blood pressure, seizures, hallucinations, sweating, nausea, vomiting, dizziness and drowsiness. In patients who are hypertensive, concomitant use of phenytoin and clopidogrel may reduce the risk of tic and cardiovascular hemorrhage. Phenytoin is not for use in pregnant, lactating, or immunocompromised women in patients with known hypersensitivity to it. Phenytoin may impair the judgement, motor skills and judgment in patients with psychotic disturbances. It is not known whether phenytoin passes into breast milk or if the drug crosses placental barrier. Consult your doctor before giving a child phenytoin. Phenytoin should be used with caution in patients heart failure as well with diabetes, congestive heart failure, peripheral neuropathy, cerebrovascular disorders, chronic obstructive pulmonary disease, or hypertension. Oral Phenytoin has been reported to cause the following metabolic side effects: altered mental status symptoms, increased metabolic rate, hallucinations, hypertension and altered mental status. This information is not meant to replace the advice given by your doctor or pharmacist during the prescribing process. 1L = 1mg/mL
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Corrected phenytoin level uk 1.14 (range 0.82–1.75) 0.88 (0.64–1.24) 0.85 (0.47–1.46) uk 4.14 (1.40–9.32) 1.39 (0.90–2.30) 1.44 (0.73–2.88) a Phenytoin equivalents (1 mg/kg body weight). b,c Phenytoin equivalent equivalents (1 mg/kg body weight) adjusted for weight in kg. d Injectable phenytoin equivalents (1 mg/kg body weight). e Injection phenytoin equivalents (1 mg/kg body weight). F ig. 1. View largeDownload slide Data for the different formulations of phenytoin. Values in mg/kg body weight. e,f Phenytoin equivalent (μg/kg body weight). These equations differ slightly as they incorporate the weight‐adjusted conversion to micrograms of phenytoin. g,h Phenytoin equivalent (μg/kg body weight). These equations differ slightly as they incorporate the weight‐adjusted conversion to micrograms of phenytoin. i A 1 (μg/kg body weight) = β A 1/2 + β A 3/4 ( μ µ g d ) If the dose is expressed as micrograms of phenytoin, α 1, and 2 are the respective amounts of phenytoin in micrograms at the appropriate time; α 3 is that dose multiplied by 100 and α 4 is that dose multiplied by the weight of patient. j number micrograms at the time drug is prescribed. k The phenytoin equivalent (μg/kg body weight). The dose of drug in micrograms phenytoin multiplied over the number of micrograms at time the dose is given. The dose of ethinyl propionate in the daily dosage unit of phenytoin varied from 1.0 to 1.5 mg/day, with an average of 1.5 mg/day (Tobler, 2000). The lowest dose was for patients taking only the daily dosage unit and highest for those taking the four formulations. drug store online uk lowest was 50 mg/day for intravenous formulation, and the highest was 2.5 mg/day for intravenous, orally Phenytoin 30 20mg - $137 Per pill administered formulations and oral hydromorphone (Tobler 2000). The daily dosage unit (50 mg) of ethinyl propionate contained phenytoin 2,000 to 2,500 micrograms as an aqueous salt, in proportion to the weight of patient (40%). daily phenytoin dose for oral products was 40 mg in three daily doses of 40 mg each and in one six‐hour dose of 40 mg each (Tobler 2000). The daily dose of oral medication phenytoin, in micrograms of active ingredient as an aqueous salt, was generally increased over time in the dose of 40 mg/day in several formulations for use by patients with mild to moderate pain. As noted, the dosage of daily phenytoin was adjusted (for those patients who needed it) by adding either 1.5 mg of phenytoin, or 0.5 a phenylpropanolamine component in 0.2 mg phenytoin base, based on the patient's weight. A small amount of phenylpropanolamine was also usually added. The added propranolol component was used to offset any increase in intraocular, intracranial or peripheral side‐effects associated with the daily dosage unit that occurred at higher levels of the drug (Tobler 1999). In addition the dose of phenylpropanolamine for extraocular administration may have been reduced (Tobler 1999). Each of the formulations phenytoin contained 0.4 g/day of ethyl propionate, 1 mg propionate and 0.3 g ethyl butyrate in the oral dosage unit (Tobler 1999). The dose of ethinyl propionate in the oral dosage unit of phenytoin for short‐term use was increased by 0.6 mg/day for three days in separate doses of 2.4–6 mg/day. The third dose, 2.4 mg/day, was chosen because the other doses were not effective, due to inadequate concentration or absorption, due to side effects, most notably peripheral or intraocular side effects (Tobler 1999). In addition, each of the three daily doses propionate containing 0.3 g of ethyl Over the counter drug similar to prednisone propionate also contained 0.3 g of ethyl esters propionate (Gillespie, et al 2005).
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